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KMID : 1103720160740020075
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Journal of the Korean Society of Radiology
2016 Volume.74 No. 2 p.75 ~ p.81
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Relationship between Framingham Risk Score and Coronary Artery Calcium Score in Asymptomatic Korean Individuals
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Heo So-Young
Park Noh-Hyuck
Park Chan-Sub
Seong Su-Ok
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Abstract
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Purpose: We explored the association between Framingham risk score (FRS) and coronary artery calcium score (CACS) in asymptomatic Korean individuals.
Materials and Methods: We retrospectively analyzed 2216 participants who underwent routine health screening and CACS using the 64-slice multidetector computed tomography between January 2010 and June 2014. Relationship between CACS and FRS, and factors associated with discrepancy between CACS and FRS were analyzed.
Results: CACS and FRS were positively correlated (p < 0.0001). However, in 3.7% of participants with low coronary event risk and high CACS, age, male gender, smoker, hypertension, total cholesterol, diabetes mellitus, and body mass index (BMI; ≥ 35) were associated with the discrepancy. In the diagnostic prediction model for discrepancy, the receiver operating characteristic curve including factors associated with FRS, diastolic blood pressure (≥ 75 mm Hg), diabetes mellitus, and BMI (≥ 35) showed that the area under the curve was 0.854 (95% confidence interval, 0.819?0.890), indicating good sensitivity.
Conclusion: Diabetes mellitus or obesity (BMI ≥ 35) compensate for the weakness of FRS and may be potential indicators for application of CACS in asymptomatic Koreans with low coronary event risk.
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KEYWORD
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Coronary Artery Disease, Vascular Calcification, Multidetector Computed Tomography
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